Paolo Bonaldo Selected Research

Scleroatonic muscular dystrophy

12/2021	Ablation of collagen VI leads to the release of platelets with altered function.
1/2019	Autosomal recessive Bethlem myopathy: A clinical, genetic and functional study.
1/2018	Collagen VI is required for the structural and functional integrity of the neuromuscular junction.
4/2016	Deep RNA profiling identified CLOCK and molecular clock genes as pathophysiological signatures in collagen VI myopathy.
1/2016	Collagen VI-NG2 axis in human tendon fibroblasts under conditions mimicking injury response.
11/2014	Muscle proteomics reveals novel insights into the pathophysiological mechanisms of collagen VI myopathies.
10/2014	NIM811, a cyclophilin inhibitor without immunosuppressive activity, is beneficial in collagen VI congenital muscular dystrophy models.
1/2014	Cyclosporin A Promotes in vivo Myogenic Response in Collagen VI-Deficient Myopathic Mice.
5/2013	Mitochondrial dysfunction and defective autophagy in the pathogenesis of collagen VI muscular dystrophies.
4/2011	Autophagy induction rescues muscular dystrophy.

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Paolo Bonaldo Research Topics

Disease

22	Scleroatonic muscular dystrophy 12/2021 - 12/2003
21	Muscular Diseases (Myopathy) 11/2020 - 12/2003
17	Bethlem myopathy 12/2021 - 12/2003
16	Muscular Dystrophies (Muscular Dystrophy) 11/2020 - 12/2008
10	Neoplasms (Cancer) 01/2020 - 05/2005
8	Fibrosis (Cirrhosis) 01/2019 - 03/2009
7	Mitochondrial Diseases (Mitochondrial Disease) 01/2014 - 12/2003
4	Wounds and Injuries (Trauma) 01/2016 - 01/2014
3	Inborn Genetic Diseases (Disease, Hereditary) 12/2017 - 04/2008
2	Hypertension (High Blood Pressure) 10/2018 - 03/2006
2	Contracture 12/2017 - 01/2011
2	Muscular Atrophy (Muscle Atrophy) 01/2016 - 01/2013
2	Heart Failure 05/2014 - 11/2010
2	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 04/2012 - 05/2009
2	Melanoma (Melanoma, Malignant) 03/2012 - 11/2005
1	Hemorrhage 12/2021
1	Edema (Dropsy) 04/2020
1	Cardiomyopathies (Cardiomyopathy) 01/2019
1	Idiopathic Pulmonary Fibrosis 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Gingival Hypertrophy 12/2017
1	Infertility (Sterility) 12/2017
1	Hyaline Fibromatosis Syndrome 12/2017
1	Mucopolysaccharidosis II (Hunter Syndrome) 01/2017
1	Connective Tissue Diseases (Connective Tissue Disease) 01/2017
1	Neuromuscular Diseases (Neuromuscular Disease) 01/2016
1	X-Linked Bulbo-Spinal Atrophy 01/2016
1	Alopecia (Baldness) 10/2015
1	Osteoarthritis 05/2015
1	Atrophy 08/2014
1	Cardiac Arrhythmias (Arrythmia) 05/2014
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 05/2014
1	Acute Pain 03/2014
1	Obesity 02/2014
1	Type 2 Diabetes Mellitus (MODY) 02/2014
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2014
1	Inflammation (Inflammations) 02/2014
1	Keloid 01/2014
1	Keratosis 01/2014
1	Skin Abnormalities 01/2014
1	Cicatrix (Scar) 01/2014
1	Body Weight (Weight, Body) 01/2014
1	Burnett Schwartz Berberian syndrome 01/2014
1	Myocardial Infarction 03/2012
1	Infarction (Infarctions) 03/2012
1	Vascular Tissue Neoplasms 03/2012
1	Brain Neoplasms (Brain Tumor) 03/2012
1	Metabolic Bone Diseases (Osteopenia) 02/2012

Drug/Important Bio-Agent (IBA)

52	CollagenIBA 12/2021 - 12/2003
10	Proteins (Proteins, Gene)FDA Link 04/2020 - 05/2009
8	Extracellular Matrix ProteinsIBA 11/2020 - 04/2008
7	Cyclosporine (Ciclosporin)FDA LinkGeneric 10/2014 - 01/2007
4	Collagen Type VIIBA 01/2019 - 03/2009
3	CateninsIBA 01/2019 - 10/2015
3	Mitochondrial Permeability Transition PoreIBA 10/2014 - 07/2008
2	Pharmaceutical PreparationsIBA 01/2020 - 06/2009
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2019 - 01/2014
2	Biomarkers (Surrogate Marker)IBA 01/2019 - 07/2013
2	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2018 - 02/2009
2	elastin microfibril interface located protein (emilin)IBA 10/2018 - 01/2016
2	Beclin-1IBA 12/2016 - 11/2010
2	Ion Channels (Ion Channel)IBA 05/2015 - 04/2008
2	Cyclophilins (Cyclophilin)IBA 10/2014 - 06/2009
2	Proteasome Endopeptidase Complex (Proteasome)IBA 12/2013 - 11/2013
2	UbiquitinIBA 12/2013 - 11/2013
2	OligomycinsIBA 07/2008 - 12/2003
1	ChemokinesIBA 11/2020
1	Laminin (Merosin)IBA 11/2020
1	Initiator Codon (Start Codon)IBA 04/2020
1	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 01/2019
1	Fos-Related Antigen-2IBA 01/2019
1	MicroRNAs (MicroRNA)IBA 01/2019
1	ErbB Receptors (EGF Receptor)IBA 10/2018
1	Interleukin-8 (Interleukin 8)IBA 01/2018
1	Cholinergic ReceptorsIBA 01/2018
1	Membrane Proteins (Integral Membrane Proteins)IBA 12/2017
1	Messenger RNA (mRNA)IBA 12/2016
1	RNA (Ribonucleic Acid)IBA 04/2016
1	Androgen Receptors (Androgen Receptor)IBA 01/2016
1	polyglutamineIBA 01/2016
1	Fibronectins (Fibronectin)IBA 01/2016
1	(melle-4)cyclosporinIBA 10/2014
1	S-NitrosothiolsIBA 08/2014
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 08/2014
1	Tyrosine (L-Tyrosine)FDA Link 08/2014
1	Adenosine Triphosphatases (ATPase)IBA 05/2014
1	Ouabain (G Strophanthin)IBA 05/2014
1	Cardiac GlycosidesIBA 05/2014
1	Recombinant ProteinsIBA 03/2014
1	Peptide Hydrolases (Proteases)FDA Link 02/2014
1	EnzymesIBA 02/2014
1	CardiotoxinsIBA 01/2014
1	Biological ProductsIBA 07/2013
1	Contractile ProteinsIBA 01/2013
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 03/2012

Therapy/Procedure

10	Therapeutics 01/2019 - 01/2007
3	Drug Therapy (Chemotherapy) 01/2020 - 07/2013
1	Protein-Restricted Diet (Diet, Protein Restricted) 12/2016
1	Stem Cell Transplantation 02/2014
1	Glycemic Control 02/2014